Geroprotective activity of trans-cinnamic acid isolated from the Baikal skullcap ( Scutellaria baicalensis)

Trans-cinnamic acid is a phenolic compound with wide range of bioactive properties, including antioxidant and antibacterial effects. It also has high potential in the food cosmetic industries. We aimed to isolate trans-cinnamic from Baikal skullcap (Scutellaria baicalensis) study its geroprotective activity on Caenorhabditis elegans nematodes used as model organism.
 Our objects included S. baicalensis root culture extract, isolated C. nematodes. was by high-performance liquid chromatography. The acid’s studied evaluating effect at concentrations 10, 50, 100, 200 μmol/L lifespan, stress resistance, reproductivity elegans. For lifespan study, were cultivated 20°C for 61 days. To assess their resistance oxidative stress, 15 μL 1M paraquat added each well plate. Thermal determined raising temperature 33°C. S-medium addition Escherichia coli OP50 required 72 h.
 maximum increase (9.8%) observed treated 50 acid. Under all increased survival nematodes, while under thermal reduced percentage surviving At concentration 100 μmol/L, nematodes’ reproduction 1.48 times.
 Based our data, can be recommended activity. However, further research needed other organisms detailed toxicity studies.